![]() It can enable you to get better perspectives on the risk connected with sensitization. Molecular allergology takes diagnostics one step further. Recombinant technology in the field of allergology has brought tremendous advances in allergen characterization as well as in the knowledge of immune mechanisms involved in allergic diseases. This Molecular Allergology User's Guide will be another breakthrough in this regard. Atlases and Guidelines represent a comprehensive set of documents that are distributed for improving appraisal and proper management of allergy. As part of its mission, the European Academy of Allergy and Clinical Immunology-EAACI-has started a project aimed to translate best knowledge into best practice. There is a need to improve the care of allergic patients through better education of health professionals and the public. Allergy is currently a public health issue although hugely underestimated and under-recognized. Many children suffer from severe food allergy and anaphylaxis, many adolescents and young adults are underperforming due to asthma and allergic rhinitis, and many adults are missing work due to comorbidities of allergic diseases. PART C – CROSS-REACTIVE MOLECULES & THEIR CLINICAL RELEVANCEĬ03 – Non-specific Lipid Transfer Proteins (nsLTPs)ĭ01 100 Important Allergenic Molecules and their Characteristicsĭ02 Glossary of Immunological Assays in Molecular AllergologyĪllergic diseases are still steadily rising and affecting a large number of individuals who are also facing an overall worsening of their clinical manifestations at any point during their lifetime. PART B – USING MOLECULAR ALLERGOLOGY IN THE CLINICAL PRACTICEī07 – Allergic Bronchopulmonary Aspergillosis (ABPA)ī08 – Role of Microbial Allergens in Atopic Dermatitisī09 – Molecular Diagnostics in the Management of Food Allergyī13 – Allergy to Crustacean and Mollusks (Shellfish) PART A – MOLECULAR ALLERGOLOGY: GENERAL CONCEPTSĪ01 – Allergology from Extracts to Molecules: Integrating Tradition with InnovationĪ02 – Allergens and the Allergenic Composition of Source MaterialsĪ03 – Molecular Allergy Diagnostics in Clinical PracticeĪ04 – Methods for IgE Antibody Testing: Singleplex and Multiplex AssaysĪ05 – Skin test, Basophil Activation Test (BAT) and Provocation Tests The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. Part D lists 100 important allergen molecules. ![]() Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. The availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled ‘component-resolved diagnosis’ (CRD).
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